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Early toxicology testing is emerging as one of the mostsignificant areas of drug discovery. Toxicity is no longer something that can be left to the development stage, or just a small part of ADMET. Toxicity determinations are an integral part of all aspects of drug discovery & development.

This report, Early Toxicology Markets and Approaches, focuses on markets for early toxicology testing services. The objective of this report is to focus the reader’s attention on the issues and opportunities related to early toxicology testing in drug discovery. It begins with an overview of drug discovery, ADMET, and early toxicology testing. It continues with some of the ways big pharmaceutical developers dealwith early toxicology. Several areas are covered, including: http://www.bharatbook.com/healthcare-market-research-reports/early-toxicology-markets-and-approaches.html

For the purposes of reporting market size and growth forecasts, the report segments the market into the following:
In Silico Approaches
Databases
Data Mining Tools
Modeling
In Vitro Assays and Platforms
Biochemical Assays
Cellular Assays
Instruments & Platforms
In Vivo Testing
Mice & Traditional Animals
Zebrafish Models
Other Animals
Human Microdosing
Early Tox Services
In Silico Services
In Vitro Services
In Vivo Services

Market analysis in this report considers primarily the availabilityof products, number and type of clinical trials active, primary endpoints, anddevelopment of new products. The marketfocuses on the United States region and, where available, discusses the marketglobally. All sales are displayed at the manufacturers’ level in U.S.dollars. Although the sales figures aredisplayed at the manufacturers’ level, in many instances, this figurerepresents a close comparison to the retail level as many end users are purchasing directly from the manufacturer.The base year is 2011, with forecasts provided for each year through 2016.  Business Report

Early toxicology is done not only to discover problem compounds, but provide directions for compound development. Early toxicology gives more than just a yes/no answer. It provides predictions of how the compound will interactwith cells, tissues, organs, systems, and the whole human. It can also show howa cell responds to a candidate compound. Various in vivo, in vitro, and in silico approaches have been evolving ever since. The objective of this report is to focus the reader’s attention on the issues and opportunities related to early tox testing in drug discovery, including:

Market Size of Segments and Subsegments within Toxicology
Forecasts of Expected Future Revenue Growth
Review of R&D Spending Trends
Discussion of Various Big Pharma Approaches to Early Toxicology Testing
Consideration of Emerging Tools and Techniques
Revenues of Top Toxicology Service Companies
The Views of Interviewed Experts in the Field
The Key Competitors and their Product and Service Offerings.

At first glance, drug discovery can appear to be a straightforward process of screening compound candidates, optimizing leads, performing pre-clinical evaluations and then, with these steps completed, clinical trials can begin. The reality is not so neat. These activities often overlap, merge, and conflict with each other. So ADME (Absorption, Distribution, Metabolism, Excretion) and Toxicology are not simply a step in lead optimization, they are actually an integral part of an ongoing process.

The report begins with an overview of drug discovery, ADMET, and early tox testing. It continues with some of the ways big pharmas deal with early tox. The next four chapters deal with the markets for in-silico, in-vitro, and in-vivo early tox products, and with the suppliers of early tox services. Product, company and market information are provided in each of these chapters. Opinions of the experts on basic issues are provided in Chapter Seven. The report concludes with profiles of 30 representative suppliers, the products they provide and their approach to the market.

CHAPTER ONE: EXECUTIVE SUMMARY
Drug Discovery: A Complex Process Viox
Baycol
Rezulin
FenPhen
Drug Development Summary
Scope and Methodology
Market Overview
Competitors

CHAPTER TWO: INTRODUCTION TO EARLY TOXICOLOGY
Overview
The Cost of Drug Development
The Role of Contract Research Organizations
Toxicology Measurement Issues
Alternative Approaches to Early Toxicity

CHAPTER THREE: PHARMA STRATEGIES AND TOXICOLOGY TACTICS
Overview
Abbott: Developing Their Own Tools
Bristol-Myers Squibb: Reducing Drug Attrition
Eli Lilly & Company: In Silico And In Vitro Methods
Glaxo Smithkline: Global Safety Board
Johnson &Johnson: Alliances And Biomarkers
Novartis: Modeling & Simulation
Pfizer: Collaborative Approach

CHAPTER FOUR: IN SILICO APPROACHES: DATABASES AND MODELING
Background
Databases
Data Mining And Analysis
In-Silico Modeling Standard Tests
Commercial Modeling Products
Advanced Chemistry Development (ACD)
Bio-Rad
GeneGo
Gene Logic
IDBS
Ingenuity Systems
KNIME
Simulations Plus
Predicting Toxicity With Qsars And Expert Modeling Systems
Government Agency And Public Initiatives
EPA’s NCCT and CompTox
FDA

For more information kindly visit :
Early Toxicology: Markets and Approaches

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